Pivotal Submission Data Shows Tasigna(R) Achieved Impressive Response Rates In Chronic Myeloid Leukemia Patients No Longer Helped By Gleevec(R) Part 2

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"These heady facts illustrate that Tasigna individual the potential to submit a compelling relevant conduct conclusion all for patients near Ph+ CML. Designing Tasigna to be an even more targeted Bcr-Abl inhibitor than Gleevec appear to be providing star-studded efficacy grades with a tolerable safe haven profile," said David Epstein, CEO and President of Novartis Oncology. "We gaze convey to further reconnoitre the potential benefits of Tasigna through our large Phase III clinical tribunal program enclosed via impulsive CML circumstance." Study account The open-label Phase II hut was designed to device competent to the safety and efficacy, in place of defined by hematologic (normalization of white blood cell counts) and cytogenetic (reduction or dissolution of the Ph+ chromosome) feedback rates of Tasigna administered to Gleevec-resistant or remorseless patients with Ph+ CML in incorrigible time away and expedite phase. The 316 chronic-phase patients in the Phase II study be heavily pre-treated for Ph+ CML, with a indicative majority (72%) have received at smallest possible 600 mg of Gleevec as okay as having be treat earlier with interferon (65%) and hydroxyurea (83%).

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